How long has it been since you've read Jeffrey Eugenides’s Middlesex? If you haven't cracked it since it was a huge hit in 2003 (or if you've never read it at all), now's the time. This gorgeous, generous, and funny novel has two hearts: a story about immigrants, and a story about the perils and difficulties of a complex gender identity in a straight male/female world. It's timely in both respects and has aged very well. The novel's scope is so delightfully huge—to me, some of the best novels are about basically everything—that a short summary is futile.
"I was born twice: first, as a baby girl, on a remarkably smogless Detroit day of January 1960; and then again, as a teenage boy, in an emergency room near Petoskey, Michigan, in August of l974. . . My birth certificate lists my name as Calliope Helen Stephanides. My most recent driver's license...records my first name simply as Cal."